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Glutamine is the most abundant amino acid (building block of protein) in the body. The body can make enough glutamine for its regular needs, but extreme stress (the kind you would experience after very heavy exercise or an injury), your body may need more glutamine than it can make. Most glutamine is stored in muscles followed by the lungs, where much of the glutamine is made.


Glutamine is important for removing excess ammonia (a common waste product in the body). It also helps your immune system function and appears to be needed for normal brain function and digestion.

You can usually get enough glutamine without taking a supplement, because your body makes it and you get some in your diet. Certain medical conditions, including injuries, surgery, infections, and prolonged stress, can lower glutamine levels, however. In these cases, taking a glutamine supplement may be helpful.

When the body is stressed (from injuries, infections, burns, trauma, or surgical procedures), it releases the hormone cortisol into the bloodstream. High levels of cortisol can lower your body' s stores of glutamine. Several studies show that adding glutamine to enteral nutrition (tube feeding) helps reduce the rate of death in trauma and critically ill people. Clinical studies have found that glutamine supplements strengthen the immune system and reduce infections (particularly infections associated with surgery). Glutamine supplements may also help in the recovery of severe burns.

Conditions

  • Immunity
  • Muscle building

Recommendations

  • Rehydrate after training sessions with a glutamine-rich drink or glutamine tablets
  • Glutamine appears to be safe in doses up to 14 g or higher per day.
  • Pediatric

    For children 10 years and younger: Do not give glutamine to a child unless your doctor recommends it as part of a complete amino acid supplement.For children 10 - 18 years: Doses of 500 mg, 1 - 3 times daily, are generally considered safe.

    Adult

    For adults ages 18 and older: Doses of 500, 1 - 3 times daily, are generally considered safe. Doses as high as 5,000 - 15,000 mg daily (in divided doses) may be prescribed by a health care provider.

    As an oral rinse for radiation therapy-induced mucositis and chemotherapy-induced stomatitis: Place 16 gm (one tablespoonful) of glutamine powder in 240 ml (8 ounces) normal saline or sterile water and mix. Then, swish 30 - 60 ml (1 - 2 ounces) and spit out, 4 times a day.

Interactions & Side Effects

  • Antiseizure medications. Use only with medical supervision
  • Protease inhibitors for HIV or cancer chemotherapy drugs. Glutamine may reduce intestinal side effects
  • Cancer therapy -- Glutamine may increase the effectiveness and reduce the side effects of chemotherapy treatments with doxorubicin, methotrexate, and 5-fluorouracil in people with colon cancer. Preliminary clinical studies suggest that glutamine supplements may prevent nerve damage associated with a medication called paclitaxel, used for breast and other types of cancers.

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Disclaimer: This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regime, it is advisible to seek the advice of a licensed healthcare professional.

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